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Updated: Jun 27, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Ts2O介导的无氧化C2-二二甲基化类N-氧化物与CS2和氨基
Long-Yong Xie1, Chu Liu1, Si-Yu Wang1
1College of Chemistry and Bioengineering, Hunan University of Science and Engineering Yongzhou 425100 China longyongxie@yeah.net ps807055147@126.com.
一种新方法有效地使用Ts2O和易于获得的原料制造oline-dithiocarbamate化合物. 这种无过渡金属的协议为各种新型化合物提供了一条实用的途径.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
背景情况:
- 奎诺林衍生物是药物化学中的重要支架.
- 开发高效的合成路径到功能化类素至关重要.
研究的目的:
- 报告一种用于林N-氧化物的新型脱氧化滴氧化协议.
- 建立一个实用和高效的林二甲基酸盐化合物的合成.
主要方法:
- 使用Ts2O作为反应的促进剂.
- 在现场从二硫化碳 (CS2) 和氨基酸生成dithiocarbamic酸.
- 在没有过渡金属的条件下进行反应.
主要成果:
- 实现了目标转换的通用,高效和实用的协议.
- 合成了各种各样的新奇oline-dithiocarbamate化合物. 合成了各种各样的新奇oline-dithiocarbamate化合物.
- 已证明具有广泛的功能组耐受性,适合高产量.
结论:
- 报告的方法为oline-dithiocarbamates提供了一个有价值的新合成策略.
- 没有过渡金属的性质和操作的简单性使得该协议非常适用.
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