雅普驱动着风湿性关节炎患者心血管疾病的发展
Guozhu Che1, Ying Liu1, Na Zhang1
1Shanxi Bethune Hospital, Department of Rheumatology and Immunology, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyu, China.
Journal of medical biochemistry
|May 3, 2024
概括
在风湿性关节炎患者心血管疾病 (RA-CVD) 中,血清YAP水平升高. YAP可以通过影响炎症,新陈代谢和血栓形成来推动RA中的心血管疾病的发展.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 分子生物学分子生物学
背景情况:
- 类风湿性关节炎 (RA) 与心血管疾病 (CVD) 的风险增加有关.
- 了解关联RA和CVD的分子机制对于患者管理至关重要.
- 在RA-CVD病原体中YAP (Yes相关蛋白) 的作用需要进一步研究.
研究的目的:
- 在RA和同时存在心血管疾病 (RA-心血管疾病) 的患者中研究YAP的血清水平.
- 评估YAP水平与实验室发现,成像结果和RA-CVD患者的疾病活性之间的关联.
- 探索YAP在RA患者心血管疾病发展中的潜在作用.
主要方法:
- 一项涉及RA-CVD患者 (n=60),没有心血管疾病的RA患者 (RA-nCVD) (n=60) 和健康对照组 (n=60) 的比较研究.
- 使用定量逆转录聚合酶连锁反应 (qRT-PCR) 来量化血清YAP水平.
- 疾病活动,心血管疾病风险因素和成像检测结果被评估并与YAP水平相关联.
主要成果:
- 与RA-nCVD患者和健康人群相比,RA-CVD患者的血清YAP水平显著更高.
- YAP水平与疾病活动标志物 (DAS28),脂质谱 (TG),炎症标志物 (CRP),血小板计数 (PLT),心血管风险评分 (FRS),心脏生物标志物 (BNP) 和动脉硬 (cIMT) 有积极的相关性.
- 在RA-CVD患者中观察到高水平的炎症标志物,改变的脂质样本和特定的心脏成像发现.
结论:
- 在RA-CVD患者中,血清YAP水平升高.
- 在RA患者心血管疾病的发展中,YAP可能起到关键的调解作用.
- YAP影响炎症反应,脂质代谢,糖代谢和血栓形成,有助于RA中心血管疾病的发病.
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