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一个新的HLA-C*03变体,HLA-C*03:620,在一个中国人身上被发现

Wenwen Pi1, Ying Li1, Chen Chen1

  • 1HLA Typing Laboratory, Blood Center of Zhejiang Province, Hangzhou, China.

HLA
|May 3, 2024
PubMed
概括

一个新的人类白细胞抗原 (HLA) 基因,HLA-C*03:620,已被确定. 这种新等位基因与HLA-C*03:04:01:02的区别在于,在3.个元区内发生的单个核酸变化.

关键词:
在HLA-C*03:620的测试中.这是下一代测序.一个新型的等位基因

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...