在产前乳酪中发现人乳寡糖:一个案例研究
Annalee Fürst1, Breanna Ford1, Hailey Hentschel1
1Department of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), and the Human Milk Institute (HMI), University of California San Diego, La Jolla, California, USA.
概括
产前大奶粉在怀孕早期含有全谱母乳寡糖化物 (HMO). 这种大奶粉为新生儿提供高度的多种HMO,与母亲尿液不同.
科学领域:
- * 人类哺乳研究研究
- * 新生儿营养新生儿营养
- * 葡萄糖生物学家
背景情况:
- * 关于产前大奶粉成分的数据有限,特别是关于母乳寡糖化物 (HMO) 的数据.
- * HMO是母乳中的关键生物活性成分,影响婴儿肠道微生物群和免疫力.
- *了解产前大奶粉的组成对于优化婴儿营养和健康结果至关重要.
研究的目的:
- * 为了描述产前大奶的母乳寡糖化物 (HMO) 组成.
- * 为了比较产前大奶粉中的HMO与母亲尿液和产后牛奶中的HMO.
- * 为了确定HMO和乳糖在整个怀孕和产后的度和变化.
主要方法:
- * 一个健康的捐赠者提供了从怀孕19周到产后3个月的产前胆乳和尿液样本.
- *使用高性能液态色谱分析HMO成分.
- * 酶检测测定了乳糖度.
主要成果:
- *HMO的完整光谱,典型的非分泌物,在怀孕19周的产前胆乳中存在 (7.5 mg/mL).
- * HMO度在怀孕30周达到峰值 (>12.5 mg/mL),随后包括分娩后在内下降.
- * HMO和乳糖度的显著变化发生在出生时;产前乳母乳HMO与尿样不同.
结论:
- *产前乳房是从怀孕早期开始的各种HMO的丰富来源.
- * 孕产妇尿液分析不能完全反映出产前大奶粉的HMO成分.
- * 早期发起的产前大奶粉养为新生儿提供了HMO的全面概况.
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