中度大动脉缩与增加的死亡率和寿命损失有关:对409 680名患者重建的时间到事件数据的系统审查和元分析
Xander Jacquemyn1,2, Jordan B Strom3, Geoff Strange4
1Department of Cardiovascular Sciences KU Leuven Leuven Belgium.
Journal of the American Heart Association
|May 3, 2024
概括
中度大动脉狭窄症 (AS) 显著增加死亡风险,并减少寿命与没有/轻度AS相比. 这一发现凸显了中度AS的低估危险,影响了一般和心力衰竭人群的生存率.
科学领域:
- 心脏病学 心脏病学
- 临床研究 临床研究
- 公共卫生 公共卫生
背景情况:
- 与中度大动脉狭窄 (AS) 相关的死亡风险尚未得到充分了解,并且经常被低估.
- 以前的评估还没有完全捕捉到中度AS对所有原因死亡率的影响.
研究的目的:
- 评估中度大动脉狭窄和全因死亡之间的关联.
- 为了比较中度AS患者与无/轻度AS患者的生存结果,包括一般和心力衰竭人群.
主要方法:
- 在2023年6月之前发表的10项研究 (409,680名患者) 的重建时间到事件数据的系统审查和元分析.
- 分析了Kaplan-Meier生存数据,以比较中度AS和无/轻度AS组之间的结果.
主要成果:
- 中度AS与显著更高的死亡风险有关 (一般人群的HR为2.55,心力衰竭患者的HR为1.83).
- 中度AS的15年生存率为23.3%,无/轻度AS为58.9%;心力衰竭的10年生存率为15.5%vs37.3%.
- 中度AS与寿命大幅减少有关 (总体为4.4年,心力衰竭为1.9年).
结论:
- 中度大动脉狭窄与死亡风险显著增加有关.
- 与没有/轻度AS患者相比,中度AS患者的整体寿命显著减少.
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