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芯片上的瘤模型用于预测in vivo纳米粒子行为

Kim E de Roode¹, Khadijeh Hashemi¹, Wouter P R Verdurmen¹

¹Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, Nijmegen, 6525 GA, The Netherlands.

Small (Weinheim an der Bergstrasse, Germany)

|May 3, 2024

概括

微流体瘤芯片模型通过模拟瘤微环境 (TME) 来增强癌症治疗研究. 这些先进的体外模型改善了对纳米粒子输送的预测,尽管蛋白质冠状和细胞分裂需要进一步研究.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症研究癌症研究

背景情况:

纳米化药物配方对于改善癌症治疗至关重要.
预测体内纳米粒子 (NP) 行为是复杂的,因为瘤微环境 (TME).
微流体瘤芯片模型为NP向提供先进的体外测试.

研究的目的:

审查最先进的微流体瘤芯片模型,用于研究纳米粒子向固体瘤输送.
根据分隔和细胞组成对这些模型进行分类.
批判性地评估它们在模拟TME时的生理相关性.

主要方法:

瘤微环境 (TME) 的描述.
微流体瘤芯片模型的分类 (单/多隔间,仅瘤/TME).
对现有模型的生理相关性的批判性评估.

主要成果:

与2D培养和静态3D球形相比,微流体瘤芯片模型显著改善了TME模拟.
这些模型增强了对瘤环境中的纳米粒子行为的理解.
蛋白冠状和细胞瘤对NP传递的影响需要进一步调查.

结论:

微流体瘤芯片系统代表了体外癌症研究的重大进步.
需要进一步精细化,专注于了解蛋白质冠状和细胞酶的作用,以提高预测能力.
这些模型对于推进基于纳米粒子的癌症疗法至关重要.

关键词:

药物输送是药物输送的过程.纳米颗粒是一种纳米粒子.蛋白质冠状病毒冠状病毒瘤向向向的目标在芯片上的瘤

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