用的对比介质给药后的甲状腺功能障碍风险:一个潜在的纵向队列分析
Seo Young Sohn1, Kosuke Inoue2,3, Muhammad T Bashir4
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang 10475, Republic of Korea.
概括
含的对比介质 (ICM) 很少会导致长期的甲状腺功能障碍,即使在充足的个体中也是如此. 建议在ICM注射后进行有针对性的监测,以检测潜在的甲状腺问题.
科学领域:
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 离子对比介质 (ICM) 经常用于放射性手术.
- 在医疗保健机构中,ICM的使用是过度暴露的重要来源.
研究的目的:
- 为了前性地评估在含有的对比剂后甲状腺功能障碍的长期风险.
- 评估ICM暴露后甲状腺激素水平的纵向变化.
主要方法:
- 一项纵向队列研究,涉及122名接受ICM的美国退伍军人事务患者.
- 血清甲状腺功能,抗体和炎症标志物在基线测量,并随访长达36个月.
- 混合效应模型被用来分析甲状腺功能障碍和激素水平变化的风险.
主要成果:
- 11.5%的参与者在平均18个月的随访期间出现了诱导的甲状腺功能障碍.
- 观察到新发的甲状腺功能障碍 (4.9%) 和亚临床甲状腺功能障碍 (6.6%).
- 甲状腺激素在参考范围内的细微纵向变化在队列中被注意到.
结论:
- 由于ICM的过量负荷,存在罕见但持续的甲状腺功能障碍的风险.
- 针对性甲状腺监测是有必要的,以为对比剂的管理后的患者,即使在充足的人群.
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