基于N-Hydroxyalkanamide的Organo/hydrogels作为pH-依赖的Metronazole和Theophylline释放的新型支架
Monika1, Meenakshi1, Mettle Brahma2
1Department of Chemistry, School of Basic Sciences, Central University of Haryana, Mahendergarh, Haryana, 123031, India.
Chemistry & biodiversity
|May 3, 2024
概括
新的N-hydroxyalkanamide凝器有效地封装了美特罗尼达和西奥菲林,改善了药物输送. 这些凝对肺癌细胞具有抗癌活性和抗菌性质.
科学领域:
- 材料科学 材料科学 材料科学
- 药物运输 药物运输 药物运输
- 纳米技术纳米技术
背景情况:
- 传统的甲基尼达和西奥菲林的药物输送面临着诸如味道不佳,吸收变化和副作用等挑战.
- 基于凝的系统提供了有针对性的交付,减少副作用和更好的患者遵守的潜力.
研究的目的:
- 为了合成具有成本效益的N-基甲胺凝剂,以改善美트로尼达和西奥菲林的输送.
- 评估开发的凝系统的体外抗癌和抗菌疗效.
主要方法:
- 单步合成具有不同链长度的N-基胺凝剂.
- 在DMSO/水中形成器官/水凝,然后进行药物封装.
- 在37°C时通过pH触发的凝到溶液过渡来评估药物释放.
- 在A549肺腺癌细胞的体外细胞毒性测定和对大肠杆菌和黄金杆菌的抗菌试验.
主要成果:
- 在N-hydroxyalkanamide凝器中,在最低凝度为1.5% w/v时,形成稳定的器官/水凝.
- 通过pH触发的凝到溶液过渡观察到药物释放.
- 载有神叶素的凝 (16HAD+Th) 对A549细胞的IC50为19.23±0.6μg/mL.
- 含有甲基醇的凝 (16HAD+Mz) 对A549细胞的IC50为23.75±0.7μg/ml.
- 凝系统对克拉姆阴性 (大肠杆菌) 和克拉姆阳性 (金黄色杆菌) 细菌表现出显著的抗菌活性.
结论:
- 具有成本效益的N-hydroxyalkanamide凝剂可以合成,以增强美트로尼达和西奥菲林的药物输送.
- 开发的凝系统在体外显示出有前途的抗癌和抗菌活性.
- 这种方法提供了一个可行的策略,以改善治疗结果和患者的遵守.
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