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狂犬病单克隆抗体充电变体的分离和表征

Ambika Divase1,2, Sambhaji Pisal1, Manjusha Sudhakar Dake2

  • 1Serum Institute of India Pvt. Ltd. Hadapsar, Pune, Maharashtra, India.

Electrophoresis
|May 3, 2024
PubMed
概括

狂犬病重组单克隆抗体 (mAb) 的制造涉及常见的充电变体. 这项研究发现,这些充电变体不会影响抗体的功能,也不需要去除.

关键词:
酸性变体的酸性变体基本的变体 基本的变体关键的质量属性 关键的质量属性狂犬病单克隆抗体 狂犬病单克隆抗体

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Rabies01:28

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Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...