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Updated: Jun 27, 2025

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
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在药物开发中评估和减轻pH介导的DDI风险 - 配方方法和临床考虑

Di Wu1, Jiaying Liu1, Erickson M Paragas2

  • 1Pharmaceutical Sciences & Clinical Supply, Merck & Co., Inc, Rahway, NJ, USA.

Drug metabolism reviews
|May 3, 2024
PubMed
概括

通过pH介导的药物相互作用 (DDI) 是常见的,特别是对于弱基. 生物预测方法和基于生理学的生物制药建模 (PBBM) 可以准确评估降酸剂 (ARA) -DDI,减少开发负担,并可能放弃临床研究.

关键词:
阿拉迪迪是什么意思在 PBPK 建模中使用 PBPK 模型.生物相关的溶解.临床研究的设计.策略的制定策略的制定.通过pH介导的药物相互作用.弱基础 弱基础的基础.

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