一种pH/温度双响应的水凝的合成和表征,其具有有前途的生物相容性特征,用于响应刺激的5-FU输送
Purushottam Suryavanshi1, Shriram Mahajan2, Sanjay K Banerjee2
1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Changsari 781101, Assam, India. subham@niperguwahati.in.
Journal of materials chemistry. B
|May 3, 2024
概括
这项研究介绍了一种新型,非有毒的水凝,由聚N-异烯胺 (PNIPAM) 制成,可应对温度和pH值. 这种对刺激有反应的水凝显示了对5-甲 (5-FU) 的受控释放,用于潜在的药物输送应用.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 刺激反应性水凝为生物医学应用提供可调节的特性.
- 基于聚N-异烯胺 (PNIPAM) 的材料因其热敏性行为而被广泛探索.
- 控制药物释放仍然是治疗应用中的一个重大挑战.
研究的目的:
- 合成和表征一种基于PNIPAM的新型triblock共聚合物水凝,具有双温度和pH响应.
- 为了研究开发的水凝的刺激反应行为和药物释放动力学.
- 评估合成共聚合物的生物相容性,用于潜在的 in vivo 应用.
主要方法:
- 合成p(NIPAM-co-DABP-co-AAc) 三阻合聚合物水凝,使用2,4'-二烯酸 (DABP) 和烯酸 (AAc).
- 系统地调查温度和pH响应性行为,包括确定较低的临界溶液温度 (LCST).
- 在体外和体内毒性评估和使用5-甲 (5-FU) 的药物加载/释放研究.
主要成果:
- 合成的水凝表现出双刺激反应性质,LCST在30°C左右.
- 这种共聚物体表现出极好的生物相容性,在体外和体内无毒.
- 实现了高药物载荷能力 (>85%为5-FU) 和受控释放,受温度和pH的影响.
结论:
- 开发的基于PNIPAM的水凝是一种有希望的,无毒的材料,用于控制药物输送.
- 根据温度和pH值,水凝的可调节释放配置允许针对性的治疗策略.
- 这项研究为设计各种生物医学应用的先进刺激响应材料铺平了道路.
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