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对多个候选益生菌细菌的调查揭示了其在修改关键伤口病原体影响的能力方面的特异性
Muna Alhubail1, Andrew J McBain2, Catherine A O'Neill1
1Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom.
Microbiology spectrum
|May 3, 2024
概括
益生菌提取物对伤口病原体具有多种作用. 一些抑制生长和生物膜的形成,而另一些可能刺激病原体的生长,突出需要谨慎的菌株选择局部应用.
科学领域:
- 微生物学 微生物学
- 皮肤病学 皮肤病学
- 益生菌研究 益生菌研究
背景情况:
- 益生菌正在研究针对皮肤病原体的局部疗法.
- 局部益生菌应用的安全性和有效性,特别是在受损皮肤上,需要进一步研究.
- 益生菌提取物在局部使用时可能比活细菌具有优势.
研究的目的:
- 评估益生菌超立体和溶解体对伤口病原体生长和生物膜形成的抑制作用.
- 评估益生菌提取物保护人类角质细胞免受病原体诱导的毒性的能力.
- 确定不同益生菌提取物对伤口病原体的特定物种影响.
主要方法:
- 来自五种候选益生菌 (Lactiplantibacillus plantarum,Limosilactobacillus reuteri,Bifidobacterium longum,Lacticaseibacillus rhamnosus GG,Escherichia coli Nissle 1917) 的超和超声波溶解物进行了测试.
- 评估了对伤口病原体的抑制作用:金黄色葡萄球菌,白杆菌 pyogenes,大肠杆菌, Pseudomonas aeruginosa 和 Acinetobacter baumanni.
- 评估了对病原体生长,生物膜形成和角质细胞保护的影响.
主要成果:
- 益生菌超级生物降低了S. aureus,大肠杆菌和A. baumanni的生长;B. longum还抑制了P. aeruginosa.
- 益生菌溶解剂抑制了S. pyogenes (L. plantarum,L. reuteri) 和大肠杆菌/S. 黄金色 (B. 长).
- 一些益生菌提取物,特别是中和的Lactobacillus超级生物和E. coli Nissle 1917溶解物,对病原体生长和生物膜形成产生了多种或刺激作用,L. reuteri和E. coli Nissle保护了角质细胞.
结论:
- 益生菌提取物,包括乳酸菌和大肠杆菌尼斯尔溶解物,可以独立于酸化来抑制病原体的生长.
- 益生菌提取物可以以特定物种的方式有益地改变宿主细胞-病原体相互作用.
- 这项研究强调,由于对病原体的可变影响,需要仔细选择益生菌物种和菌株用于局部应用.
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