开发和评估多草本植物体凝的疗效,以加速伤口愈合
Babita Shukla1,2, Poonam Kushwaha1, Sumedha Saxena3
1Faculty of Pharmacy, Integral University, Lucknow, India.
Journal of biomaterials science. Polymer edition
|May 3, 2024
概括
这项研究开发了一种使用Curcuma longa和Plumbago zeylanica提取物来改善伤口愈合的新型植物体凝. 与传统治疗相比,这种增强的配方显示出优异的伤口收缩和更快的愈合.
科学领域:
- 药理学和植物化学
- 药物输送系统 药物输送系统
- 皮肤病学和伤口护理
背景情况:
- 长和Plumbago zeylanica由于多化合物而具有抗氧化,抗炎和伤口愈合的特性.
- 这些化合物的有限水溶性阻碍了它们的治疗效果.
- 植物体封装增强了难溶性植物成分的生物可用性和透性.
研究的目的:
- 制定和评估一种基于植物体的多草药凝,含有P. zeylanica和C. longa的甲醇提取物,用于伤口愈合.
- 为了研究开发的多草本植物体凝的伤口愈合潜力.
- 评估封装草本提取物的增强生物可用性和治疗疗效.
主要方法:
- 用脂膜水化技术将P. zeylanica根和C. longa根茎的甲醇提取物封装成植物体.
- 优化的植物体分散 (F7) 被纳入基于碳烯的水凝矩阵中.
- 实验室释放,稳定性研究和体内切除伤口模型被用于评估.
主要成果:
- 植物体配方的特点是封装效率,颗粒大小,多分散度指数和泽塔潜力.
- 与传统配方相比,植物体凝表现出持续的药物释放.
- 在体内研究表明,植物体凝增强了伤口收缩和减少了表皮质化时间.
结论:
- 含有P. zeylanica和C. longa提取物的多草本植物体凝配方显示出治疗伤口的巨大潜力.
- 植物体技术有效地提高了草本提取物的生物可用性和伤口愈合效果.
- 这种新的配方为局部伤口护理应用提供了一个有希望的方法.
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