在绝经前妇女中,阿司匹林代谢物和乳房扫描乳腺密度

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Ramkrishna K Singh¹, Kayla R Getz¹, Joy K Kyeyune²

¹Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

|May 3, 2024

概括

这项研究发现血中的阿司匹林代谢物与绝经前妇女的乳腺密度 (MBD) 之间没有明确的联系. 需要进一步的研究来了解MBD决定因素和乳腺癌预防.

科学领域:

生物化学生物化学
在瘤学瘤学.
流行病学流行病学

背景情况:

乳房扫描乳腺密度 (MBD) 是乳腺癌的一个重要风险因素.
之前关于阿司匹林使用和MBD的研究已经产生了相互矛盾的结果.
研究阿司匹林代谢物提供了更精确的方法来了解潜在的关联.

研究的目的:

检查阿司匹林代谢物和乳房扫描乳房密度 (MBD) 在绝经前妇女之间的关系.
通过血液样本的代谢分析分析来探索关联.
为了解乳腺癌预防的MBD决定因素作出贡献.

主要方法:

通过使用代谢分析分析了705名绝经前妇女的血液样本.
采用了与共变量调整的线性回归模型.
评估了MBD (VPD,DV,NDV) 的体积测量与阿司匹林代谢物的四分位数 (盐酸氨基葡萄糖,2-基氨酸,酸盐,2,6-二基酸) 相比.

主要成果:

与非使用者相比,阿司匹林使用者表现出某些阿司匹林代谢物 (盐酸氨基葡萄糖胺,2-基酸盐,酸盐) 的水平较高.
在阿司匹林使用者中,氨酸葡萄胺水平呈现出剂量和频率相关的增加.
在阿司匹林代谢物和体积测量MBD (VPD,DV,NDV) 之间没有观察到单调的关联.

结论:

该研究发现,在绝经前妇女中,测量阿司匹林代谢物和乳房扫描乳腺密度之间没有显著的单调关联.
需要对乳腺组织中的阿司匹林代谢物度进行进一步的研究.
未来的研究还应该探索非阿司匹林NSAID代谢物和MBD之间的关联.

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