在心力衰竭中,在休息状态下增加了交感介导的血管收缩,但在运动期间保持完整的功能性交感解体,心力衰竭中减少了射出分数
Natasha G Boyes1, M Rafique Khan1, Adam M S Luchkanych1,2
1College of Kinesiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
概括
患有心力衰竭和减少喷射率 (HFrEF) 的患者经历过度的血管收缩. 然而,手握运动使这种反应正常化,这表明HFrEF的功能性同理解被保存.
科学领域:
- 心血管生理学心血管生理学
- 运动生理学 运动生理学
- 心脏衰竭病理生理学 病理生理学
背景情况:
- 患有心力衰竭和减少射出分数 (HFrEF) 的患者表现出较高的同情活动和损伤的外周血管控制.
- 有限的证据存在于功能性交感解体,在运动期间减少交感血管收缩,在HFrEF.
研究的目的:
- 在HFrEF中量化了在同情激发期间肢体血管导电率的减少.
- 为了确定功能性交感解可以减轻HFrEF的这些减少.
主要方法:
- 20名HFrEF患者和22名对照人接受了单独的冷压力测试 (CPT) 和同时进行的手握运动 (EX + CPT).
- 测量了前臂血管导电 (FVC),前臂血流 (FBF) 和平均动脉压 (MAP).
主要成果:
- 与对照组相比,HFrEF患者在CPT期间的%ΔFVC和%ΔFBF下降幅度更大.
- 在CPT期间,手握运动消除了过度血管收缩,并在HFrEF患者的FVC和FBF中恢复正常.
- 在CPT和EX + CPT期间,MAP在两组中都增加,在EX + CPT期间,对照组的MAP更高.
结论:
- 急性同情激发导致过度的外周血管收缩和减少HFrEF中的血液流动.
- 手握运动有效地抵消了交感刺激性血管收缩,在HFrEF中保持正常的血液流动和血管导电性.
- 这些发现表明HFrEF患者上肢的功能交感解质完好,突出显示在运动期间保持了局部血流控制.
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