在体力活动期间为患有1型糖尿病的儿童提供自动胰岛素:元分析
Yuan-Yuan Wang1, Hui-Min Ying1, Fang Tian1
1Department of Endocrinology, 631689 Xixi Hospital of Hangzhou , Hangzhou, Zhejiang Province, P.R. China.
概括
自动化胰岛素输送系统 (AID) 改善了范围的时间,并减少了1型糖尿病 (T1D) 儿童的高血糖症. 然而,与其他系统相比,AID并没有显著降低运动后低血糖.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 生物医学工程 生物医学工程
背景情况:
- 儿童群体的1型糖尿病 (T1D) 管理存在独特的挑战,特别是在体力活动期间.
- 自动化胰岛素输送系统 (AID) 为优化青少年和患有T1D的儿童的血糖控制提供了一个潜在的解决方案.
研究的目的:
- 评估自动胰岛素输送 (AID) 系统在青少年和患有1型糖尿病 (T1D) 的儿童体育活动期间的疗效.
- 为了比较AID与传统胰岛素系统在运动期间管理T1D的性能.
主要方法:
- 在Cochrane图书馆,PubMed和Embase进行了系统的文献搜索.
- 关键词包括"儿童"",胰岛素输液系统"和"糖尿病".
- 分析了12项涉及514名患者的研究.
主要成果:
- 艾滋病辅助系统在体力活动期间没有显著减少低血糖持续时间 (p>0.99).
- 与非AID相比,使用AID的时间范围 (TIR) 显著更高 (p<0.001).
- 在AID组中,高血糖时间显著降低 (p<0.05).
结论:
- 自动注射胰岛素 (AID) 改善TIR,并降低了儿童T1D患者的高血糖.
- 与开放循环或传感器增强相比,AID在降低运动后低血糖症方面没有显著的益处.
- 需要进一步的研究来证实AID对体力活动期间低血糖持续时间的潜在益处.
相关概念视频
Insulin: Dosing Regimen and Adverse Effects
168
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
168
Diabetes Mellitus: Overview and Type I Subtype
2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K
Insulin Formulations: Types and Delivery
191
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
Short-acting insulins are divided into...
191
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Diabetes: Management and Pharmacotherapy
268
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
268


