肝硬化的病因对静脉血栓栓塞的风险的影响
Gayatri Pemmasani1, William Tremaine2, Raffi Karagozian3
1Division of Gastroenterology and Hepatology, SUNY Upstate Medical University, 750 E Adam St, Syracuse, NY, 13202, USA. gpemmasani0524@gmail.com.
Digestive diseases and sciences
|May 3, 2024
概括
与与酒精有关的或病毒性肝硬化相比,非酒精性脂肪肝 (NASH) 肝硬化与静脉血栓栓塞 (VTE) 的风险更高. 了解NASH肝硬化中这种增加的VTE风险对于更好的患者管理至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心血管医学 心血管医学
- 胃肠病学 胃肠病学
背景情况:
- 肝硬化显著增加出血和静脉血栓栓塞 (VTE) 事件的风险.
- 不同肝硬化病因对VTE风险的具体影响仍然不够理解.
研究的目的:
- 调查和比较各种肝硬化病因,包括非酒精性脂肪肝炎 (NASH),病毒性和与酒精有关的病因的VTE和门静脉血栓塞 (PVT) 的风险.
- 分析肝硬化病因与VTE/PVT风险之间的关联,使用大型国家数据库.
主要方法:
- 对2019年美国全国再接收数据库的回顾性分析.
- 包括因NASH,病毒或与酒精有关的病因诊断出肝硬化病的住院患者.
- 在这些病因群体中识别和比较急性VTE,慢性VTE和PVT的发病率.
主要成果:
- 非酒精性脂肪性肝炎 (NASH) 肝硬化呈现出最高的整体VTE率 (10.8%),其次是病毒性 (9.7%) 和与酒精有关的 (7.5%) 肝硬化.
- 在风险调整后,NASH肝硬化 (OR 1.48) 和病毒性肝硬化 (OR 1.22) 与与酒精有关的肝硬化相比显示出明显更高的VTE风险.
- 病毒性肝硬化有最高的PVT率 (4.3%),病毒性肝硬化 (OR 1.61) 和NASH肝硬化 (OR 1.41) 与酒精相关肝硬化相比,PVT的调整后风险增加.
结论:
- 与与酒精相关和病毒相关的病因相比,非酒精性脂肪肝 (NASH) 肝硬化与静脉血栓栓塞 (VTE) 的风险显著增加有关.
- 鉴于NASH作为肝硬化的主要原因的患病率不断上升,认识到其与增加VTE风险的联系对于完善临床治疗和改善患者的治疗结果至关重要.
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