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治疗过度活跃膀的患者的抗胆固醇负担:用神经刺激作为解决方案的二线治疗

Nihal Satyadev^1,2, Maryam Ameen³, Trieu H Do⁴

¹Department of Neurology, Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL, 3224, USA. satyadev.nihal@mayo.edu.

International urogynecology journal

|May 3, 2024

概括

过度活性膀 (OAB) 管理指南可能需要更新. 神经刺激 (TNS) 为抗胆固醇药物提供了一个潜在的更安全的替代品,这些药物与痴呆风险有关.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
神经学神经学
老年病的医生老年病的医生

背景情况:

过度活跃的膀 (OAB) 是常见的,并且通常具有同时发生的条件.
目前的OAB治疗指南建议首先使用非药物方法,然后使用抗胆固醇药物.
神经刺激 (TNS) 以前被认为是第三线疗法,因为人们认为成本和可访问性问题.

研究的目的:

根据新的证据,重新评估OAB管理准则.
为了比较TNS (PTNS和TTNS) 与抗胆固醇药物的疗效,副作用和成本.
倡导将TNS纳入作为二线OAB治疗.

主要方法:

该评论确定并比较了两种类型的TNS:穿皮神经刺激 (PTNS) 和穿皮神经刺激 (TTNS).
与抗胆固醇药物的比较是基于疗效,副作用概况和成本.
在最近的发现的背景下讨论了指导方针建议.

主要成果:

越来越多的证据将抗胆固醇药物使用与痴呆症联系起来.
穿皮神经刺激 (TTNS) 最近获得了FDA的批准,增加了其可访问性.
与抗胆固醇药物相比,TNS疗法在某些方面表现出与抗胆固醇药物相比的可比性或优异性.

结论:

最近的发现需要对当前的OAB管理准则进行审查.
神经刺激 (TNS) 是抗胆固醇药物的可行且潜在的更安全的替代品.
更新的指导方针应该考虑TNS作为OAB在抗胆固醇药物之前的第二线治疗选择.

关键词:

抗胆固醇药物抗胆固醇药物失禁失禁是一种失禁.神经刺激神经刺激过度活动的膀.

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