美国数字队列中的不规则周期,排卵障碍和心脏代谢状况
Zifan Wang1, Anne Marie Z Jukic2, Donna D Baird2
1Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
JAMA network open
|May 3, 2024
概括
多囊卵巢综合征 (PCOS) 和不规则的月经周期与心脏代谢状况的增加有关. 对周期不规律的早期查可能有利于妇女的健康.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 心血管医学 心血管医学
- 代谢健康 代谢健康
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种常见的排卵障碍,其特点是月经周期不规律和高雄性质.
- 不规则的周期是心脏代谢状况的潜在标志物,但PCOS特定关联的数据有限.
研究的目的:
- 评估PCOS的关联,初潮以来的月经规律的时间,以及成年期不规则的周期与心脏代谢条件的关联.
- 通过生活方式因素来调查这些关联的潜在修改.
主要方法:
- 使用来自果研究应用程序的大型美国数字队列 (N=60,789) 的横截面研究.
- 通过调查收集了关于PCOS诊断,月经规律的时间,不规则的周期和心脏代谢状况的自我报告数据.
- 使用后勤回归模型来估计流行概率比率 (POR) 和95%置信区间 (CI).
主要成果:
- 脊髓灰质炎症与更高的代谢和心血管疾病的患病率有关,包括心律不整,冠状动脉疾病,心脏病发作和中风.
- 在没有PCOS的参与者中,长时间的规律性与2型糖尿病,高血压,心律失常和过渡性缺血性发作 (TIA) 有关.
- 不规则的周期与2型糖尿病,高胆固醇,心律失常和TIA有关,一些关联因体重指数和体力活动而改变.
结论:
- 过多囊性卵巢综合症和不规则的月经周期可以作为心脏代谢状况的独立标志物.
- 这些发现强调了在心脏代谢风险评估中考虑月经周期规律的重要性.
- 对于有不规则月经周期的个体,早期查和干预可能有助于预防不良的心脏代谢结果.
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