IGF2,IGF2R和IGF2BP2基因多态与妊娠糖尿病的关联:一个病例对照研究
Wei Li1, Lu She2, Muyu Zhang1
1Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
PloS one
|May 3, 2024
概括
在中国人群中,IGF2,IGF2R和IGF2BP2基因的遗传变异与妊娠期糖尿病 (GDM) 风险无关. 然而,一种多态性 (rs6777038) 显示了与较低的葡萄糖水平的潜在关联.
科学领域:
- 遗传学 是一个遗传学.
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
背景情况:
- 孕期糖尿病 (GDM) 对母亲和胎儿的健康构成风险.
- 遗传因素与GDM易感性有关.
- 研究特定的基因多态性可以阐明GDM的病原性.
研究的目的:
- 检查IGF2,IGF2R和IGF2BP2基因中的多态化与GDM风险之间的关联.
- 探索影响GDM易感性的潜在基因相互作用.
- 分析这些多形态在怀孕期间对葡萄糖代谢的影响.
主要方法:
- 病例控制研究涉及1703名孕妇 (835名GDM,868名非GDM).
- 使用Sequenom MassARRAY选定的单核酸多态体 (SNPs) 的基因定型.
- 使用了后勤回归和多因素缩小维度 (MDR) 分析.
主要成果:
- 在对共变量进行调整后,研究的基因多态 (IGF2 rs680,IGF2R rs416572,IGF2BP2 rs4402960,rs1470579,rs1374910,rs11705701,rs6777038,rs16860234,rs7651090) 和GDM风险之间没有发现显著的关联.
- 在候选SNP中没有发现显著的基因相互作用.
- IGF2BP2 rs6777038多态性与显著降低的空腹血糖和2小时后口服葡萄糖耐受性测试 (OGTT) 葡萄糖水平有关.
结论:
- 在IGF2,IGF2R和IGF2BP2基因中研究的多态性与研究中华人群体的GDM易感性没有显著联系.
- IGF2BP2 rs6777038多态可能会影响葡萄糖代谢,需要进一步研究.
- 建议进行更大规模的多中心研究来证实这些发现,并探索GDM的其他遗传因素.
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