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危急的COVID-19,Victivallaceae丰富度和腹腔炎:一个调解的门德尔随机化研究

Yuxin Zou¹, Manyi Pan¹, Tianyu Zhou¹

¹Department of Respiratory and Critical Care Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

|May 3, 2024

概括

危急的COVID-19可能会通过减少保护性肠道细菌来增加乳病风险. 这项研究使用遗传数据来探索2019年冠状病毒病和肠道微生物群介导的腹腔疾病之间的因果关系.

科学领域:

免疫学免疫学免疫学
胃肠病学胃肠病学
遗传学是一个遗传学.

背景情况:

在2019年冠状病毒病 (COVID-19) 患者中,乳病 (CeD) 的患病率较高,但因果关系尚不清楚.
肠道微生物群的改变与COVID-19和CeD有关.
调查COVID-19和CeD之间的遗传因果关系,用肠道微生物群作为调解者,至关重要.

研究的目的:

通过两步的门德尔随机化方法调查COVID-19和腹腔疾病之间的潜在因果关系.
检查肠道微生物群在COVID-19和腹腔疾病风险之间的关联中扮演的调解角色.
评估COVID-19感染,住院和危急疾病对乳病风险的影响.

主要方法:

采用两步门德尔随机化 (MR) 方法,利用全基因组关联研究 (GWAS) 数据.
为COVID-19暴露选择的遗传仪器变量.
评估了COVID-19对乳病风险和肠道微生物群的影响,以及微生物群的调解作用.

主要成果:

临界的COVID-19显着与患乳病的风险增加有关 (P=0.035).
危急的COVID-19显示与Victivallaceae (P=0.045) 的丰富性有反向相关性.
增加Victivallaceae的丰富性显示出对乳病风险的保护作用 (P=0.016).

结论:

提供了基因证据,证明危急的COVID-19和增加腹腔疾病风险之间的因果关系.
表明,减少Victivallaceae的丰富性介导了在危急的COVID-19之后患乳病的风险增加.
突出了肠道微生物群在病理生理学中可能发挥的作用,该病理生理学将严重的COVID-19和腹腔疾病联系起来.

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