早期可行性研究使用可植入的近红外光谱传感器检测葡萄糖,酸盐,乳酸盐和乙醇
Francesca De Ridder1,2, Rie Braspenning1, Juan S Ordonez3
1Department of Endocrinology-Diabetology-Metabolism, Antwerp University Hospital, Antwerp, Belgium.
PloS one
|May 3, 2024
概括
这项研究表明,第一个可植入的传感器可以安全地监测葡萄糖,酸盐,乳酸盐和乙醇. 近红外光谱传感器在跟踪这些关键代谢物的过程中表现出精确性.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 代谢学 代谢学 代谢学
背景情况:
- 持续的多代谢物监测对于管理各种健康状况至关重要.
- 现有的监测方法往往需要侵入性程序,或者仅限于单个分析物.
- 植入式传感器的开发为实时,全面的代谢评估提供了一个有希望的途径.
研究的目的:
- 评估可植入近红外 (NIR) 光谱传感器的安全性和性能.
- 评估传感器对同时监测葡萄糖,,乳酸盐和乙醇的能力.
- 在不同的生理条件下确定传感器的准确性和可靠性.
主要方法:
- 一项早期可行性研究 (NCT04782934) 涉及7名参与者 (4名1型糖尿病患者,3名健康患者).
- 植入阳光光谱传感器28天.
- 代谢挑战诱导葡萄糖,,乳酸盐和乙醇水平的变化,与血液和呼吸测量进行比较.
主要成果:
- 植入式传感器是安全的,耐受性很好,没有传染病或伤口愈合并发症.
- 在七个传感器中,有六个在整个研究期间保持了完整的功能.
- 对葡萄糖 (MARD 7.4%), (MAD 0.12 mM),乳酸 (MAD 0.16 mM) 和乙醇 (MAD 0.18 mM) 进行了精确的测量,常见混因素对葡萄糖读数没有显著影响.
结论:
- 首个用于多生物标志物监测的植入式传感器显示出出色的耐受性.
- 传感器为葡萄糖,,乳酸盐和乙醇提供了准确的测量.
- 这项技术代表了持续代谢监测的重大进步.
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