老年营养风险指数与腹腔透析患者的临床结果之间的关联:元分析
Renjie Wang1, Yuxiang Liang, Jiaojiao Jiang
1Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Medicine
|May 3, 2024
概括
低老年营养风险指数 (GNRI) 与腹腔透析 (PD) 患者的结果更差有关. 该指数可能有助于预测PD患者的死亡率和不良事件.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 老年病的医生 老年病的医生
- 营养科学 营养科学
背景情况:
- 老年营养风险指数 (GNRI) 是一种营养评估工具.
- 腹腔透析 (PD) 是一种常见的置换疗法.
- 在PD患者中GNRI的预后价值需要进一步调查.
研究的目的:
- 确定GNRI与PD患者的临床结果之间的关联.
- 评估GNRI作为PD患者死亡率和其他不良事件的预测指标.
主要方法:
- 进行了对队列研究的系统审查和元分析.
- 从PubMed,EBASE,Web of Science和CNKI数据库中确定了研究,截至2023年12月25日.
- 评估了所有原因的死亡率,PD退出,主要不良心脏和脑血管事件 (MACCE),技术失败和腹膜炎.
主要成果:
- 纳入了10项研究,包括3897名患者.
- 较低的GNRI与所有原因死亡率的增加显著相关 (HR=0.71,P=0.007).
- 降低的GNRI预测了更高的PD退学率 (HR=0.971,P=0.034) 和MACCE (HR=0.95,P=0.001). 这两种预测的结果是:
- 在GNRI和技术失败或腹膜炎之间没有发现显著的关联.
结论:
- 低GNRI是PD患者临床结果不佳的重要预测因素.
- 对于接受腹膜透析的个人来说,GNRI可以作为一个有价值的预后指标.
- 正如GNRI指出的营养状况,在PD患者的管理中起着至关重要的作用.
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