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连接体重组与叶病理及其手术切除相关

Sara Larivière^1,2, Bo-Yong Park^3,4, Jessica Royer¹

¹Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC H3A 2B4, Canada.

Brain : a journal of neurology

|May 3, 2024

概括

叶 (TLE) 手术改变了大脑网络组织. 手术后,大脑整合了逆侧区域,重组与手术前海马缩和发作特征有关.

科学领域:

网络神经科学网络神经科学
人类大脑组织组织
焦点大脑病变 - 焦点大脑病变

背景情况:

通过焦点病变来理解大脑调制是不完整的.
叶 (TLE) 手术为研究损伤效应提供了一个模型.
耐药性TLE患者进行前叶切除术.

研究的目的:

评估焦点病变和切割对大脑结构连接体的下游后果.
在个体患者层面探索重组与临床变量之间的关系.
研究手术诱导的连接体重构及其临床关联.

主要方法:

扩散磁力共振成像 (MRI) 轨道图以获得结构连接组数据.
将高维连接组数据投射到低维梯度中.
在TLE患者和对照患者手术前和手术后连接体梯度的比较.
部分最小平方分析以发现临床成像特征.

主要成果:

手术前的TLE患者在temporo-parietal区域显示出改变的连接体梯度,并增加了ipsilateral前叶分离.
外科手术诱导的重组局限于temporo-parietal子网络,涉及对侧区域集成.
术后整合前皮层与手术前的斜侧海马缩,较低的发作频率和较少的次要泛性发作有关.

结论:

焦点脑损伤和手术切除显著影响大规模网络重组.
在TLE手术后的连接体重构与个人间的临床变异性有关.
这些发现为人类大脑的基本可塑性提供了新的见解.

关键词:

大脑网络大脑网络连接ome 连接ome 连接ome 焦点损伤的焦点损伤梯度梯度的梯度是指梯度的梯度.在纵向的长度上.手术手术手术手术手术手术手术

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