皮层脊髓道损伤与中风后结果之间的关联的调节 白质超强度的高强度
Jennifer K Ferris1, Bethany P Lo1, Giuseppe Barisano1
1From the Gerontology Research Centre (J.K.F.), Simon Fraser University; Department of Physical Therapy and Djavad Mowafaghian Centre for Brain Health (J.K.F.), University of British Columbia, Vancouver, Canada; Chan Division of Occupational Science and Occupational Therapy (B.P.L., M.R.D., S.-L.L.), University of Southern California, Los Angeles; Department of Neurosurgery (G.B.), Stanford School of Medicine, Stanford University, CA; Central Clinical School (A.B., M.S.K.), Monash University, Melbourne, Victoria, Australia; Department of Medicine (A.B.), Royal Melbourne Hospital, University of Melbourne, Victoria, Australia; Department of Neurology (C.M.B.), Department of Rehabilitation Medicine (C.M.B.), and Department of Radiology (C.M.B.), Emory University, Atlanta, GA; Hospital das Clinicas HCFMUSP (A.B.C.), Faculdade de Medicina, Universidade de São Paulo; Hospital Israelita Albert Einstein (A.B.C.), São Paulo, Brazil; Melbourne School of Psychological Sciences (N.E.-B.), University of Melbourne; Departments of Physiotherapy, Medicine (RMH) & The Florey Institute of Neuroscience and Mental Health (K.S.H.), University of Melbourne, Victoria, Australia; Facility for Education and Research in Neuroscience (K.P.R.), Emory University, Atlanta, GA; Brain Mapping Center (A.Z.-P.), Department of Neurology, Geffen School of Medicine, University of California Los Angeles; and Mark and Mary Stevens Neuroimaging and Informatics Institute and Keck School of Medicine (L.B., S.-L.L.), University of Southern California, Los Angeles.
白质超强度 (WMHs) 恶化了中风运动结果,并通过与皮质脊柱管 (CST) 损伤相互作用来影响恢复. 了解WMH的影响对于预测中风后的运动功能至关重要.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 脑卒中后的运动结果与皮质脊柱管 (CST) 损伤有关.
- 白质过强度 (WMHs) 与衰老共同,可能会损害大脑从中枢神经系统损伤中恢复的能力.
- WMHs对中风后运动功能的影响仍然不清楚.
研究的目的:
- 调查WMH是否调节中枢神经系统损伤和中风后运动障碍之间的关系.
- 确定CST损伤和WMH对运动结果的独立和互动影响.
主要方法:
- 利用了ENIGMA中风恢复工作组的数据,包括T1和T2/FLAIR成像.
- 使用加权的 CST 损伤负荷 (CST-LL) 量化 CST 损伤.
- 用混合效应β回归模型测量WMH体积并分析它们与CST-LL的相互作用,控制共变量.
主要成果:
- 独立预测的WMH体积运动障碍 (β = 0.178,p = 0.022).
- 在轻度WMH患者中,CST-LL对运动障碍的影响是显著的,但在中度至重度WMH患者中没有显著的影响.
- 在中度至严重的WMH病例中,运动障碍与WMH体积相关 (β = 0.299,p = 0.044),而不是CST-LL.
结论:
- WMHs显著影响中风后的运动结果,改变了CST损伤和运动障碍之间的关联.
- 与WMH相关的脑损伤可能会导致中风恢复中观察到的变异性,并且可能未被充分认识到.
- 大脑的结构储备,包括白质的完整性,对于中风后的运动恢复至关重要.
相关概念视频
The Spinal Cord
Neurogenesis and Regeneration of Nervous Tissue
Spinal Cord Injury ll: Pathophysiology
Cerebral Edema ll: Pathophysiology
Degenerative Disc Disease ll: Pathophysiology
Secondary Spinal Cord Injury llI: Pathophysiology


