增加无细胞DNA与精神分裂症患者的氧化损伤有关
Shuhui Li1, Jie Jiang1, Wenli Zhu2
1Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200030, China.
Journal of psychiatric research
|May 3, 2024
概括
细胞自由DNA (cfDNA) 水平升高是精神分裂症 (SZ) 患者的稳定指标,无论疾病的阶段或药物治疗. 这种cfDNA主要来自于细胞核,这表明与氧化应激和高血糖相关的亡增加.
科学领域:
- 生物化学 生物化学
- 遗传学 遗传学 是一个
- 神经科学是一个神经科学.
背景情况:
- 无细胞DNA (cfDNA) 在精神分裂症 (SZ) 中升高,但机制和疾病阶段相关性尚不清楚.
- 这限制了cfDNA作为SZ的诊断标记物的临床实用性.
研究的目的:
- 在SZ中研究跨疾病阶段的cfDNA度.
- 探索高cfDNA的机械关联,包括起源和相关生物标志物.
- 评估cfDNA作为SZ稳定的诊断指标的潜力.
主要方法:
- 利用改进的光相关谱法 (FCS) 方法直接测量血中的cfDNA.
- 在191名SZ患者,78名情绪障碍 (MD) 患者和65名健康对照 (HC) 中分析了cfDNA.
- 评估了cfDNA来源 (核与线粒体),氧化标记 (SOD活性) 和生化指数 (禁食血糖).
主要成果:
- SZ患者的cfDNA水平显著增加 (P=0.003),不论疾病的阶段或药物.
- 无细胞核DNA (cf-nDNA) 在SZ上升 (P=0.041),但不是无细胞线粒体DNA (cf-mtDNA).
- 降低SOD活性 (P=0.005) 和升高的禁食血糖与SZ患者的较高cfDNA水平相关 (分别P=0.047和P=0.013).
结论:
- 升高的cfDNA是一种方便,有效和稳定的SZ特征指标.
- 在SZ中cfDNA升高的主要来源是核,这表明亡增加.
- 这些发现将高cfDNA与氧化应激和精神分裂症中的高血糖症联系起来.
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