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Updated: Jun 27, 2025

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation
10:35

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation

Published on: December 26, 2017

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巴里西丁尼通过向JAK1/STAT3来调节巨细胞极化,从而保护ICI相关的心肌炎

Xuejun Wang1, Jiahui Chen2, Yihui Shen2

  • 1Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai Institute of Medical Imaging, 180 Fenglin Road, Shanghai, China; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, 180 Fenglin Road, Shanghai, China.

Cytokine
|May 3, 2024
PubMed
概括

巴里西替尼可以通过减少炎症和纤维化来保护免疫检查点抑制剂相关的心肌炎. 这种Janus激酶抑制剂调节巨细胞两极分化,为这种严重的副作用提供了潜在的治疗策略.

关键词:
巴里西提尼布 (Baricitinib) 是一种药物.免疫检查点抑制剂 免疫检查点抑制剂巨细胞的两极分化肌肉性心脏炎是一种心肌炎.编程死亡 1 编程死亡 1

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