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Updated: Jun 27, 2025

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控制cGAS:SPSB3促进核cGAS降解,以维持免疫恒温

Ruey-Hwa Chen1

  • 1Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan.

Molecular cell
|May 3, 2024
PubMed
概括

研究人员发现,CRL5-SPSB3泛素酶针对核循环GMP-AMP合成酶 (cGAS)进行降解. 这一过程防止了有害的DNA触发的免疫反应,并保持了免疫平衡.

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