灯泡膨胀最初是由人类表皮细胞模型中的透压力之后的角性活性聚合驱动的
Dhiraj Indana1, Andrei Zakharov2, Youngbin Lim3
1Department of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA.
Cell stem cell
|May 3, 2024
概括
人类胚胎的早期发育涉及由actin聚合力驱动的光形成,而不是透压力. 随着光层的扩张,这种机制转变为压力驱动的生长,确保适当的胚胎发育.
科学领域:
- 发展生物学 发展生物学
- 细胞生物学 细胞生物学
- 生物物理学的生物物理.
背景情况:
- 植入后,人体表皮质细胞形成一个中心的光线,对于胃流动至关重要.
- 奥斯摩斯压力是光膜扩张的推测驱动因素,但它在人类表皮质细胞中的作用尚不清楚.
研究的目的:
- 为了研究驱动人体表皮质细胞中的光形成的机制.
- 确定透压力和细胞力量在早期发光过程中的作用.
主要方法:
- 利用在工程水凝上培养的基于多能干细胞的表皮质细胞模型.
- 采用计算建模来模拟光线膨胀动态.
- 分析了人类表皮质细胞的转录特征.
主要成果:
- 早期表皮质细胞的漏出结节可以防止透压梯度.
- 角性活性聚合力,而不是透压力,驱动初始光线膨胀.
- 在~12微米半径的紧密结点成熟允许透压力驱动进一步的生长.
- 计算模型预测过渡到压力驱动的增长,以防止在更大的光量中曲.
- 人类表皮质体表现出支持这些发现的转录特征.
结论:
- 动氨酸聚合是早期人类表皮质细胞中光膜扩张的主要驱动因素.
- 随着光层的成熟,转变为由透压驱动的生长发生.
- 这种机制可能代表了胚胎发育早期发光的一般途径.
关键词:
这就是Actin Actin.计算建模计算建模胚胎发生是胚胎发生.工程制造的水凝人类表皮质细胞模型诱导多能干细胞的诱导干细胞.卢门 (Lumen) 是一种光线.形态发生 (morphogenesis) 是一种形态的产生.这种压力是透压力.组织生物物理学的组织生物物理.更多相关视频
10:30The C. elegans Excretory Canal as a Model for Intracellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis in a Single Cell: labeling by GFP-fusions, RNAi Interaction Screen and Imaging
Published on: October 3, 2017
9.6K
07:44Mucociliary Epithelial Organoids from Xenopus Embryonic Cells: Generation, Culture and High-Resolution Live Imaging
Published on: July 28, 2020
4.7K
相关概念视频
01:16Cell Motility through Blebbing
1.9K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
Blebbing Through the Matrix
In multicellular...
1.9K
01:31Mechanism of Lamellipodia Formation
2.5K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
2.5K