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Alex John Scott¹, Mohammed Limbada², Tahlia Perumal¹

¹Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine and University of Cape Town Lung Institute, Cape Town, South Africa; South African MRC/UCT Centre for the Study of Antimicrobial Resistance, University of Cape Town, Cape Town, South Africa.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

|May 3, 2024

概括

在社区积极寻找病例期间整合结核病 (TB) 和COVID-19的照顾点测试是可行的和有效的. 这种方法成功地使用分子和放射学工具识别感染个体.

科学领域:

传染性疾病传染性疾病
公共卫生公共卫生
诊断技术诊断技术诊断技术

背景情况:

结核病 (TB) 和COVID-19是全球重要的健康威胁.
积极寻找病例 (ACF) 对于控制社区传染病至关重要.
同时对结核病和COVID-19进行查可以提高诊断效率.

研究的目的:

评估结核病和COVID-19综合检测的诊断产量.
评估使用点照顾 (POC) 分子和放射工具进行查的可行性.
在社区ACF期间确定结核病的个体的传染性.

主要方法:

基于社区的招聘,使用移动诊所为涉嫌结核病和/或COVID-19的参与者招聘.
同时进行POC检测:Xpert Ultra用于结核病 (唾液) 和Xpert SARS-CoV-2用于COVID-19 (鼻拭子).
计算机辅助检测 (CAD) 的POC胸部放射,并通过显微镜评估结核病的传染性,咳气溶采样和放射性腔腔检测.

主要成果:

16/144 (11.1%) 的参与者检测出结核病阳性,10/144 (6.9%) 的COVID-19,其中2 (1.4%) 患有并发感染.
在16名 (43.8%) 结核病患者中,有7名可能具有传染性.
POC Xpert Ultra显示了75.0%的敏感性和96.9%的TB特异性;Xpert SARS-CoV-2显示了66.7%的敏感性和97.1%的COVID-19特异性. 结核病的CAD的AUC为0.90.

结论:

在基于社区的ACF期间,使用POC分子和放射学工具进行综合结核病/COVID-19查是可行的.
这种方法证明了这两种疾病的高诊断产量.
这一策略有效地识别出潜在的传染性个体,帮助疾病控制工作.

关键词:

在 COVID-19 疫情中,基于社区的积极案件调查.诊断诊断诊断诊断可行性可行性整合整合整合结核病是一种疾病.

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