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怀孕对胰腺的MCN的影响:一个多中心病例控制研究
Alessandro Fogliati1, Stefano Crippa2, Giovanni Marchegiani3
1Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, MN, USA; Hepatobiliary and Pancreas Surgery Unit, IRCCS San Gerardo Dei Tintori, Monza, Italy.
怀孕可能会增加胰腺粘膜性囊性瘤 (MCN) 恶性退行风险. 孕期MCN显著增长,需要为想要怀孕的患者提供多学科咨询.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 妇科 妇科医生 妇科
背景情况:
- 胰腺粘膜性囊性瘤 (MCN) 表达激素受体,病例报告表明在怀孕期间的生长.
- 孕期和MCN恶性转变之间的潜在联系需要调查.
研究的目的:
- 为了确定怀孕是否是胰腺MCN恶性退行症的危险因素.
- 评估妊娠期和高度MCN的发展之间的相关性.
主要方法:
- 对为MCN进行胰腺切除的女性患者 (2011-2021) 的回顾性分析.
- 在怀孕12个月内诊断或切除的MCN被归类为危险怀孕.
- 高度 (HG) MCN包括那些具有高度发育不良或侵入性成分的MCN.
主要成果:
- 在176名患者中,有25名 (14%) 被归类为HG-MCN.
- 周周MCN (16%) 与囊大小增加呈正相关性 (p=0.020).
- 在14名孕期MCN患者中,29%的患者有HG-MCN,71%的患者在孕期经历了显著的囊生长.
结论:
- 孕期MCN与囊直径增加和怀孕期间高生长率有关.
- 对于考虑怀孕的MCN患者,建议进行多学科咨询.
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