作为潜在的药物载体系统的ivermectin脂质体的开发和体外抗病毒活性
Meryem Kocas1,2,3, Tansel Comoglu3, Aykut Ozkul4
1Department of Pharmaceutical Technology, Selcuk University Faculty of Pharmacy, Konya, Turkey.
Archiv der Pharmazie
|May 3, 2024
概括
含有伊弗梅克的脂质体显示出对SARS-CoV-2的抗病毒活性增强. 这项研究优化了脂质体配方,以改善药物输送和病毒感染中的治疗潜力.
科学领域:
- 制药科学 制药科学
- 纳米技术 纳米技术
- 病毒学 病毒学
背景情况:
- 艾弗梅克具有广泛的抗寄生虫和抗病毒特性.
- 脂质体提供了一个有前途的药物递送系统,可以提高药物的有效性和向性.
- 优化脂肪体配方对于最大限度地提高治疗效益至关重要.
研究的目的:
- 开发和描述多种含有ivermectin的脂肪体配方.
- 为了比较不同脂质体制备方法和脂质成分的疗效.
- 评估针对SARS-CoV-2的优化配方的体外抗病毒活性.
主要方法:
- 使用脂膜水化和乙醇注射方法,制备了18种含有ivermectin的脂质体配方.
- 使用因子设计,以基于粒子大小,PDI,泽塔潜力和封装效率来优化配方.
- 试验室表征包括TEM,FTIR,药物释放研究和针对SARS-CoV-2的抗病毒分析.
主要成果:
- 优化脂肪体配方的颗粒大小约为196纳米,PDI为0.39,泽塔电位为-40.24mV.
- 封装效率超过80%,负载能力为4.00%.
- 与自由菌素相比,含有菌素的脂质体在体外显著增强了对SARS-CoV-2的抗病毒活性,较低的IC50值表明了这一点.
结论:
- 含有伊弗梅克的脂质体有效抑制SARS-CoV-2病毒活动.
- 脂质体显著改善了ivermectin的抗病毒特性和治疗潜力.
- 这些发现支持脂质体艾弗麦丁作为一种新型抗病毒疗法的发展.
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