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通过[¹⁸F]FDG PET/CTCT,通过[¹⁸F]FDG PET/CT,区分胸膜囊与低风险胸膜瘤

Sunju Choi^1,2, Yong-Il Kim³, Sangwon Han¹

¹Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

EJNMMI research

|May 3, 2024

概括

在正子发射断层扫描 (PET) /计算机断层扫描 (CT) (SUVmax ≤ 2.1) 中,低[18F]氧葡萄糖 (FDG) 的吸收 (SUVmax ≤ 2.1) 可以帮助区分胸膜囊和低风险胸膜瘤. 像PET等级和中央代谢缺陷等视觉发现也是有用的诊断标记.

科学领域:

医疗成像医学成像
在瘤学瘤学.
胸部外科手术胸部外科手术

背景情况:

胸膜囊是一种罕见的良性病变,需要与低风险的胸膜瘤区分开来.
[18F]氧葡萄糖 (FDG) 定子发射断层扫描 (PET) /计算机断层扫描 (CT) 对于胸膜囊的诊断实用性尚未得到充分证实.
这项研究研究了[18F]FDG PET/CT在区分胸膜囊和低风险胸膜瘤中的作用.

研究的目的:

评估视觉和定量[18F]FDG PET/CT发现在区分胸膜囊和低风险胸膜瘤方面的有效性.
确定可帮助对这些胸膜病变进行差异诊断的关键成像参数.

主要方法:

70名接受了手术前[18F]FDG PET/CT和乳腺切除术的患者的回顾性分析.
评估视觉PET/CT发现 (PET视觉等级,中央代谢缺陷,CT形状) 和定量参数 (SUVmax,CT直径,CT衰减).
使用皮尔森的千平方测试,曼-惠特尼U测试和接收器操作特征 (ROC) 曲线分析进行统计分析.

主要成果:

在PET视觉等级 (P<0.001),PET中央代谢缺陷 (P<0.001),PETSUVmax (P<0.001),CT直径 (P<0.001) 和CTHU (P=0.004) 中观察到胸膜囊和低风险胸膜瘤之间的显著差异.
PET SUVmax显示了最高的诊断性能,AUC为0.996 (P<0.001),达到100.0%的灵敏度和94.2%的特异性,截止值≤2.1.
对于PET SUVmax的AUC显著高于CT直径和CT HU.

结论:

低[18F]FDG吸收 (SUVmax ≤ 2.1) 是诊断胸膜囊的一个强有力的指标.
PET视觉等级和中央代谢缺陷是支持差异化的易于解释的发现.
[18F]FDG PET/CT参数,特别是SUVmax,对于区分胸膜囊和低风险胸膜瘤非常有价值.

关键词:

光氧葡萄糖F18 光氧葡萄糖F18 pozitron发射断层扫描计算机断层扫描计算机断层扫描敏感性和特异性敏感性和特异性甲状腺瘤的新生体

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