冠状病毒病和末期病患者的氧化应激:试点研究
Nam-Seon Beck1, Yeonju Seo2, Taesung Park3
1Department of Pediatrics, Chung-Ang Jeil Hospital, Chungbuk, South Korea.
BMC nephrology
|May 3, 2024
概括
患有COVID-19和末期脏疾病 (ESRD) 的患者比单独患有COVID-19的患者呈现较低的氧化应激. 在接受血液透析的ESRD患者中,补充抗氧化剂可能不会对轻度的COVID-19有好处.
科学领域:
- 生物化学 生物化学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
背景情况:
- 氧化应激在COVID-19和功能障碍中升高.
- 研究了COVID-19和末期病 (ESRD) 对氧化应激的联合影响.
研究的目的:
- 为了比较COVID-19和ESRD患者的氧化应激水平与仅COVID-19和仅ESRD患者的水平.
主要方法:
- 在三个组中比较了氧化应激标志物:COVID-ESRD (n=18),COVID (n=17) 和ESRD (n=18).
- 利用了COVID-19患者的医院数据,包括患有或没有功能障碍的患者和接受血液透析的ESRD患者.
主要成果:
- 总氧化应激在COVID-ESRD组的水平低于COVID组 (p=0.047).
- 与ESRD和COVID组相比,COVID-ESRD的总抗氧化剂状态更高 (p<0.001).与ESRD和COVID组相比,COVID-ESRD的总抗氧化剂状态更高 (p<0.001).
- 与ESRD和COVID组相比,COVID-ESRD的氧化应激指数较低 (p<0.001).与ESRD和COVID组相比,COVID-ESRD的氧化应激指数较低 (p<0.001).
结论:
- 反应性氧物种在ESRD患者的COVID-19病理生理学中发挥着非关键的作用.
- 补充抗氧化剂可能不会在血液透析的ESRD患者中为轻度的COVID-19提供治疗益处.
- 在这个领域需要进一步的研究.
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