开发新型Streptococcus equi疫苗,评估其免疫潜力和保护功效
Rafik Soliman1, Mohamed Yousef2, Sara Abdel Gelil1
1Department of Microbiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
BMC veterinary research
|May 3, 2024
概括
针对Streptococcus equi亚种的新疫苗被开发用于对抗马匹的杀. 结合的S. equi和S. zooepidemicus疫苗与MONTANIDE ISA-70辅助剂显示出显著的保护性疗效.
科学领域:
- 兽医免疫学 兽医免疫学
- 马类传染病 马类传染病
- 细菌学 细菌学是一门学科.
背景情况:
- ,一种传染性马匹呼吸道疾病,是由Streptococcus equi亚种引起的.
- 有效的疫苗对于控制马群中杀疫情的管理至关重要.
研究的目的:
- 开发和评估新型无活化疫苗,用于对抗导致杀的Streptococcus equi亚种.
- 为了比较单价疫苗与组合疫苗和不同辅助剂的疗效.
主要方法:
- 隔离和鉴定Streptococcus equi亚种. equi (S. equi) 和Streptococcus equi的亚种. 动物流行病 (S.动物流行病).
- 开发使用MONTANIDE GEL和MONTANIDE ISA-70辅助剂的四种非活化疫苗配方.
- 在挑战性研究中评估疫苗的安全性,纯度,功效,小鼠和子的免疫性,以及保护性疗效.
主要成果:
- 结合的S. equi和S. zooepidemicus疫苗添加了MONTANIDE ISA-70的辅助剂,显示出更高的保护效率.
- 在使用实验室和野外动物模型的挑战测试中,获得了75%的保护率.
- 与MONTANIDE凝相比,MONTANIDE ISA-70辅助剂显示出更大的疗效.
结论:
- 开发的联合疫苗代表了控制杀的有希望的战略解决方案.
- 使用MONTANIDE ISA-70辅助剂的疫苗配方在保护马免受杀方面非常有效.
关键词:
Streptococcus equi 是一个有毒的细菌.Streptococcus zooepidemicus 这种细菌是动物性流行病.蒙塔尼德 (Montanide) 的辅助剂一种新的联合疫苗.杀者 杀者 杀者更多相关视频
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