特定于组织学的标准化发病率比提高了对第二次原发性肺癌风险的估计
Marian Eberl1, Luana F Tanaka2, Klaus Kraywinkel3
1TUM School of Medicine and Health, Technical University of Munich, Georg-Brauchle-Ring 56, Munich, 80992, Germany. marian.eberl@tum.de.
BMC medicine
|May 3, 2024
概括
肺癌幸存者面临着第二次原发性肺癌 (SPLC) 的更高风险. 一种新的组织学特异性方法显示,使用标准规则,风险被低估了30%,改善了国际比较.
科学领域:
- 在瘤学瘤学.
- 癌症流行病学 癌症流行病学
- 生物统计学 生物统计学
背景情况:
- 肺癌 (LC) 幸存者患第二种原发性癌症 (SPC) 的风险较高.
- 第二种原发性肺癌 (SPLC) 的标准化发病率 (SIR) 可能在使用国际癌症研究机构/国际癌症注册表协会 (IARC/IACR) 多重原发性 (MP) 规则的注册表中被低估.
- 这种低估源于MP规则要求SPC分类不同的组织学,可能掩盖SPLC风险.
研究的目的:
- 评估组织学特异性参考率是否改善了LC幸存者中SPLC的SIR风险估计.
- 通过使用一种新的组织学特异性SIR计算方法,在德国提出最新的SPLC风险估计.
- 通过使用US SEER数据验证新方法,该方法采用不同的MP规则.
主要方法:
- 利用来自德国11个区域癌症登记处的基于人口的癌症登记处数据.
- 应用了一种新方法来计算组织学亚型特定的SIRs用于SPLC风险估计.
- 使用美国SEER数据验证了组织学特定的SIR方法.
主要成果:
- 调整后的SPLC的相对风险为2.98的女性和1.15的男性在德国使用组织学特定的SIR.
- 根据IARC/IACR MP规则,传统的SIR在LC幸存者中低估了SPLC风险约30%.
- 这种新方法证明了其稳定性和适合于跨国比较.
结论:
- 一种组织学特定的SIR方法提高了肺癌幸存者的SPLC风险估计.
- 这种方法在不同的注册表规则中提供了更准确和可比的SIR指标.
- 这些发现强调了组织学在准确评估SPLC风险方面的重要性.
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