在美国成年人中尿液挥发性有机化合物代谢物和COPD:混合物,相互作用和调解分析
Ying Wang1, Zhaowei Meng2, Sen Wei3
1Department of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
概括
暴露于挥发性有机化合物 (VOC) 与慢性阻塞性肺病 (COPD) 风险增加有关. 这项研究发现,VOC代谢物混合物显著增加COPD风险,特别是在非吸烟者中.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 挥发性有机化合物 (VOC) 是常见的化学物质,与COPD等呼吸道问题有关.
- 关于多个VOC暴露对COPD的综合影响的研究有限.
- 这项研究调查了VOC代谢物混合物与COPD风险之间的关联.
研究的目的:
- 评估VOC代谢物混合物对大量成年人群中COPD风险的影响.
- 确定有助于COPD风险的特定VOC代谢物.
- 探索白细胞计数和总胆红素的潜在调解.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) (2011-2020) 中的5997名成年人的数据.
- 采用多变量逻辑回归,贝叶斯加权量子素和回归 (BWQS),基于量子素的g计算 (Qgcomp) 和贝叶斯内核机器回归 (BKMR).
- 通过白细胞 (WBC) 计数和总 bilirubin 的调解进行了研究.
主要成果:
- 后勤回归表明9个VOC代谢物显著增加了COPD风险.
- 总体VOC代谢物混合物在BWQS和BKMR模型中显示出与COPD有显著的积极关联.
- 在不吸烟者中观察到VOC混合物对COPD的显著影响,白细胞计数介于这一关联的7.1%.
结论:
- 结果表明VOCs,特别是N,N-二甲基形式胺和1,3-丁,与一般人群中COPD有不良关联.
- 强调了解VOC混合物带来的健康风险的重要性.
- 强调需要采取干预措施来减少VOC暴露和减轻COPD风险.
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