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相关概念视频

Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

180
Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
180

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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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甲基评分:基于DNA甲基化的健康预测指标的综合R函数.

Zongli Xu1, Liang Niu2, Jacob K Kresovich3

  • 1Biostatistics & Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, United States.

Bioinformatics (Oxford, England)
|May 3, 2024
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概括

这项研究将158个DNA甲基化预测因子集成到R函数中,以便在表观遗传学研究中更容易使用. 新方法提高了跨研究的生物年龄和其他特征估计的精度和可比性.

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科学领域:

  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 基因组医学是基因组医学.
  • 计算生物学 计算生物学

背景情况:

  • DNA甲基化预测器对流行病学和个性化医学有价值.
  • 从原始来源生成预测因素是复杂且耗时的.
  • 阵列和批量效应阻碍了跨研究的预测器可比性.

研究的目的:

  • 将158个已发表的DNA甲基化预测因子集成到一个单一的R函数中.
  • 提供一种方法 (ref-RCP) 来减轻批量和阵列差异.
  • 提高表观遗传预测因素估计的精度和可比性.

主要方法:

  • 将158个已发表的DNA甲基化预测因子集成到一个R函数中.
  • 利用经典和主要组件的方法来生成预测器.
  • 开发了一种修改后的RCP方法 (ref-RCP) 来实现DNA甲基化数据的正常化.

主要成果:

  • 该R函数产生158个时间年龄,生物年龄,暴露,生活方式和血清蛋白质的预测指标.
  • 该ref-RCP方法将输入的DNA甲基化数据正常化为参考数据.
  • 评估表明,估计精度和跨研究可比性有所提高.

结论:

  • 集成的R函数简化了DNA甲基化预测器的使用.
  • 该ref-RCP方法提高了表观遗传学估计的可靠性.
  • 该ENmix包为表观遗传学研究和个性化医学提供了一个有价值的工具.