超尿血和静脉脂肪乳液是积极胃肠道出血期间痛风爆发的危险因素:一个病例对照研究
Yujie Jiang1, Xuelian Hong1, Bingtian Xia2
1Department of Rheumatology, Jinhua Hospital of Zhejiang University: Jinhua Municipal Central Hospital, Jinhua, 321000, China.
Advances in rheumatology (London, England)
|May 3, 2024
概括
患有痛风的患者经历胃肠道出血,患痛风爆发的风险很高. 超尿血和静脉脂肪乳液治疗显著增加这种风险,需要谨慎管理.
科学领域:
- 类风湿病学 类风湿病学
- 胃肠病学 胃肠病学
- 内部医学 内部医学
背景情况:
- 痛风患者对胃肠道出血的敏感性增加.
- 胃肠道出血期间的痛风爆发,由于抗炎药物的副作用,造成了治疗挑战.
研究的目的:
- 为了确定患有活跃胃肠道出血的患者中痛风爆发的危险因素.
主要方法:
- 对94名患有痛风,胃肠道出血的患者进行了回顾性观察性研究.
- 收集的数据包括人口统计和临床特征.
- 用多变量逻辑回归分析来确定预测因素.
主要成果:
- 在患有痛风爆发的患者中,高尿血症 (81.6%) 和静脉脂肪乳液治疗 (46.9%) 更常见.
- 超尿血症 (OR 2.741) 和静脉脂肪乳液治疗 (OR 2.645) 是痛风爆发的独立预测因素.
- 在静脉注射脂肪乳液治疗中,痛风发作发生得更快 (中位数为4天而不是5天).
结论:
- 痛风发作在胃肠道出血期间很常见.
- 患有高尿血症的患者和接受静脉脂肪乳液治疗的患者面临更高的痛风发作风险.
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