相关实验视频

Updated: Jun 27, 2025

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

Published on: April 23, 2019

无脂蛋白E ε4等位基和嗅觉功能的对气味识别网络的影响

Conner Frank¹, Abigail Albertazzi², Claire Murphy^2,3

¹SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA.

Brain and behavior

|May 4, 2024

概括

阿波利波蛋白E ε4 (ApoE ε4) 载体具有不良的气味熟悉度和识别能力,显示多网络大脑功能障碍,表明潜在的阿尔茨海默病 (AD) 风险. 嗅觉评估可以预测这些人的AD转换.

科学领域:

神经科学是一个神经科学.
老年学是指老年学的学科.
嗅觉研究嗅觉研究

背景情况:

阿波脂蛋白E ε4 (ApoE ε4) 状态,气味识别和熟悉性预测轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 的转化.
嗅觉障碍与AD风险增加有关.

研究的目的:

研究ApoE ε4载体与非载体中的嗅觉处理和大脑网络功能.
探索与AD风险相关的气味熟悉性,识别和神经网络活动/连接之间的关系.

主要方法:

功能磁共振成像 (fMRI) 用于评估在气味识别任务期间的大脑活动.
独立组件分析确定了五个与任务相关的功能网络.
多重线性回归分析了气味熟悉度,识别分数和ApoE ε4状态对网络激活和功能连接 (FC) 的影响.

主要成果:

感觉嗅觉网络的激活与具有良好的气味熟悉度的ApoE ε4载体中的气味识别具有积极的相关性.
在 ApoE ε4 载体中观察到感觉-嗅觉,多感觉-语义和尾尾网络的改变FC,具有较差的气味熟悉度和识别能力.
前部区域和感官嗅觉网络之间的连接性减少与熟悉度较低的载体中较低的气味识别得分有关.

结论:

在ApoE ε4载体中较差的气味熟悉度和识别可能表明多个大脑网络的功能障碍.
通过评估气味的熟悉性和识别,可以通过检测感官认知整合失调来提高MCI和AD风险的预测.
进一步研究患有阿尔茨海默氏症风险的个体的嗅觉处理是至关重要的.

关键词:

在这里,APOEOE是APOE.这是阿尔茨海默氏症.功能连接性的功能连接性网络连接性网络连接性嗅觉嗅觉是一种嗅觉.

更多相关视频

Simple and Computer-assisted Olfactory Testing for Mice

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

A Free-breathing fMRI Method to Study Human Olfactory Function

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

相关概念视频

Olfaction

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

Physiology of Smell and Olfactory Pathway

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...

Olfactory Receptors: Location and Structure

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...