食品中添加盐与欧洲血统的痴呆症之间的关联:孟德尔的随机化研究
Ren Zhou1, Fei Chen1, Lei Zhang1
1Department of Anesthesiology, The Ninth People's Hospital of Shanghai, Jiao Tong University School of Medicine, Shanghai, P. R. China.
Brain and behavior
|May 4, 2024
概括
高盐摄入量与痴呆症风险增加有关,包括阿尔茨海默病. 减少盐的摄入量可能是大脑健康的关键预防策略.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 高盐摄入量被怀疑是痴呆症的危险因素.
- 盐消费与痴呆症之间的因果关系尚不清楚.
研究的目的:
- 通过使用孟德尔随机化 (MR) 设计,研究盐摄入对痴呆风险的因果关系.
- 分析盐摄入量与各种认知结果之间的关联,包括阿尔茨海默病和一般认知表现.
主要方法:
- 利用全基因组关联研究 (GWAS) 的暴露和IEU数据库的结果数据.
- 使用逆变量加权 (IVW) 模型进行MR估计,并使用MR-Egger,加权中位数和MR-PRESSO方法进行补充.
- 进行了敏感性分析,包括Cochran的Q测试,MR-Egger拦截,MR-PRESSO测试,留出一个分析和漏斗图案评估,以确保稳定性.
主要成果:
- 提供了高盐摄入量与痴呆症 (OR=1.73,P=0.003),阿尔茨海默病 (AD) 痴呆症 (OR=2.10,P=0.015) 和未定义痴呆症 (OR=2.61,P=0.009) 之间的因果关系的证据.
- 较高的盐摄入量与AD风险增加有关 (OR=1.80,P=0.014) 和认知表现较差 (β=-0.133,P=0.006).
结论:
- 这项研究表明,高盐摄入量和痴呆风险增加之间存在因果关系,包括AD和未定义痴呆症.
- 减少盐的摄入量可能是预防痴呆症发展的关键预防措施.
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