患有状细胞疾病和状细胞特征的儿童免疫接种的坚持:基于人口的研究结果
Jiajing Scarlette Shi1, Ankit Sutaria2, Sangeetha Lakshmanan1
1Georgia Health Policy Center, Andrew Young School of Policy Studies, Georgia State University, Atlanta, Georgia, USA.
Pediatric blood & cancer
|May 4, 2024
概括
患有状细胞疾病 (SCD) 的儿童比患有状细胞特征的儿童有更好的免疫率. 然而,改善疫苗接种和护理协调对于所有患有SCD的儿童至关重要.
科学领域:
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 及时完成疫苗接种对于预防儿童传染病至关重要.
- 关于状细胞疾病 (SCD) 的儿童免疫坚持率的数据有限.
研究的目的:
- 为了比较患有SCD的儿童和患有状细胞特征的儿童之间的免疫坚持率.
- 为了在这些儿科队伍中确定具有较低完成率的特定疫苗.
主要方法:
- 在格鲁吉亚,回顾性队列研究分析了2008-2019年的免疫数据.
- 在SCD和状细胞特征的儿童中,24个月和35个月的完成率和最新状态的比较.
- 利用千平方测试和几率比率来评估疫苗接种率的差异.
主要成果:
- 与状细胞特征儿童相比,患有SCD的儿童在24个月和35个月的最新免疫率更高.
- 在35个月后患有SCD的儿童中,观察到总体最新状态和四剂量肺炎球菌合疫苗系列的显著更高的比率.
- 在乙型肝炎系列中,完成率最高,而天花疫苗在两组中最低. 最常错过的疫苗是白喉疫苗,破伤风疫苗,非细胞性百日咳疫苗,水疫苗和肺炎球菌联合疫苗.
结论:
- 与状细胞特征儿童相比,患有SCD的儿童表现出优越的免疫覆盖率.
- 有机会提高疫苗接种率,特别是针对特定的疫苗,如天花和肺炎球菌合疫苗.
- 建议增加SCD儿童获得护理协调服务,以确保及时提供预防性医疗保健.
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