LINC00152: 在胰腺癌中潜在的驱动性瘤基因
Wei Xu1,2, Huiting Li1,2, Ziyao Wang3
1NHC Key Laboratory of Carcinogenesis, National Clinical Research Center for Geriatric Disorders, Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Department of oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wiley interdisciplinary reviews. RNA
|May 4, 2024
概括
长非编码RNA 152 (LINC00152) 通过促进恶性瘤,化学抵抗和免疫逃脱来推动瘤的进展. 这篇评论详细介绍了LINC00152的细节.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
背景情况:
- 长非编码RNAs (lncRNAs) 是具有多种细胞功能的关键调节者.
- 从染色体2p11.2转录的LINC00152与各种癌症类型有关.
- 它在促进瘤恶性,化学抵抗和免疫逃脱方面的作用越来越被认可.
研究的目的:
- 系统地审查影响瘤LINC00152表达的上游调控因素.
- 巩固目前对LINC00152功能和机制在胰癌中的理解.
- 突出LINC00152作为驱动性瘤基因和生物标记物的潜力.
主要方法:
- 对LINC00152调节和功能研究的系统文献综述.
- 对LINC00152参与分子信号网络 (表观遗传,蛋白相互作用,ceRNA) 的分析.
- 综述LINC00152作为各种癌症的驱动性瘤基因和生物标志物的作用.
主要成果:
- LINC00152的表达是由转录因子和DNA低甲基化调节的.
- 它通过致癌表型,化学抵抗和免疫逃避影响瘤的进展.
- LINC00152参与复杂的调节网络,影响癌症的发展.
结论:
- LINC00152是一个重要的致癌性 lncRNA,在各种癌症中发挥着关键作用.
- 了解其上游调节和下游机制对于治疗策略至关重要.
- LINC00152作为泛癌生物标志物和治疗点具有前途.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
01:33Cancer-Critical Genes I: Proto-oncogenes
8.8K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.8K
03:18Non-LTR Retrotransposons
11.5K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.5K
01:06Induced Pluripotent Stem Cells
4.0K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.0K
01:20The Retinoblastoma Gene
4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K
01:12Loss of Tumor Suppressor Gene Functions
4.8K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.8K