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定量双回声稳定状态T2的可复制性 膝关节软骨的映射
Ashley A Williams1,2, Jessica L Asay3, Daniella Asare2
1Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Journal of magnetic resonance imaging : JMRI
|May 4, 2024
概括
定量双回声稳定状态 (qDESS) T2映射显示了膝关节软骨的出色可重现性. 超过5% (3.8毫秒) 的变化可能表明软骨组成的改变,有助于检测骨关节炎.
科学领域:
- 生物医学工程 生物医学工程
- 放射学 放射学是一门学科.
- 整形外科 整形外科 整形外科
背景情况:
- 膝关节软骨T2测绘可以识别患有骨关节炎的关节.
- 定量双回声稳定状态 (qDESS) 序列提供快速T2映射 (<5分钟).
- 了解qDESS T2可重现性对于其作为生物标志物的临床应用至关重要.
研究的目的:
- 为了评估膝关节软骨 qDESS T2.2. 的联合获取和细分可重复性.
- 为了比较T2分析的手动和自动次区域细分方案.
主要方法:
- 对11名健康参与者的前性研究.
- 3-特斯拉 qDESS 序列用于 T2 映射.
- 使用变化系数 (CV),根-平均-平方-平均-CV (RMSA-CV) 和类内相关系数 (ICC) 评估测试-重复测试可重复性.
主要成果:
- 在所有软骨区域和细分方法中,白天和白天 qDESS T2 CVs 和 RMSA-CVs 是 ≤5%.
- T2精度为<1.3毫秒,最小可检测差异 (SDD) 为3.8毫秒.
- 普遍观察到高的ICC值 (>0.75),尽管日间骨比较显示出更多的变化.
结论:
- 优良的CV和RMSA-CV可复制性支持使用qDESS T2进行软骨评估.
- 在qDESS T2中超过5% (3.8毫秒) 的变化可能反映了软骨组成的变化.
- qDESS T2 显示出高技术性能,用于分析膝关节软骨的健康状况.
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