癌症患者体质指数和心血管结果的变化
Kensuke Ueno1, Hidehiro Kaneko2, Yuta Suzuki3
1Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan; Department of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan.
Mayo Clinic proceedings
|May 4, 2024
概括
癌症患者经历体质指数 (BMI) 损失或增加面临心血管疾病 (CVD) 风险增加. 体重指数 (BMI) 的下降特别增加了心血管疾病事件的风险,强调了体重管理对癌症存活率的重要性.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 代谢健康 代谢健康
背景情况:
- 心血管疾病 (CVD) 是癌症患者和癌症幸存者的重要关注点.
- 在癌症治疗期间和之后,身体质量指数 (BMI) 的波动很常见.
- 了解BMI变化与心血管疾病风险之间的关系对于预防性护理至关重要.
研究的目的:
- 检查身体质量指数 (BMI) 变化与癌症患者心血管疾病 (CVD) 发生率之间的关联.
- 确定BMI变化的特定模式 (损失,稳定,增益) 以及它们对心血管疾病风险的差异影响.
主要方法:
- 一项使用JMDC索赔数据库 (2005年1月至2021年4月) 的回顾性观察研究.
- 包括52,344名没有先前心血管疾病的癌症患者,按一年BMI变化分类:损失 (≤-5.0%),稳定 (-5.0%至5.0%),或增加 (≥5.0%).
- 主要终点:复合心血管疾病事件 (心力衰竭,心房动,缺血性心脏病,中风).
主要成果:
- 在平均763天的随访期间,发生了3124次复合心血管疾病事件.
- 与稳定的BMI相比,BMI损失 (HR 1.16) 和BMI增加 (HR 1.10) 都与心血管疾病风险增加有关.
- 观察到一个U形的关联,心力衰竭和心房动风险在BMI损失和增加方面显著增加.
结论:
- 癌症幸存者具有显著的BMI损失或增加,表现出患心血管疾病的风险增加.
- 体重指数下降与心血管疾病风险增加有着特别强烈的关联.
- 癌症患者的BMI监测和管理可能对于减轻心血管并发症至关重要.
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