卵蛋白水解剂对认知表现和脑血管功能的长期影响:一项双盲随机对照试验,针对具有较高主观认知缺陷的成年人进行
Micah S Adams1, Ronald P Mensink1, Jogchum Plat1
1Department of Nutrition and Movement Sciences, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Universiteitssingel 50, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
European journal of nutrition
|May 4, 2024
概括
长期摄入卵蛋白水解剂Newtricious (NWT) -03改善了女性的执行功能和工作记忆,但男性没有,对大脑血流没有影响.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 老年学是指老年学的学科.
背景情况:
- 短期服用卵蛋白水解剂Newtricious (NWT) -03对执行功能有好处.
- NWT-03的机制和长期认知影响尚不清楚.
- 患有主观认知缺陷 (SCF) 的超重/肥胖老年人是认知健康研究的关键人群.
研究的目的:
- 研究NWT-03对SCF老年人认知表现和脑血流 (CBF) 的长期影响.
- 探索对NWT-03.3的反应中的潜在性别差异.
- 评估NWT-03对来自大脑的神经营养因子 (BDNF) 水平的影响.
主要方法:
- 一项为期36周的随机对照试验,44名超重/肥胖参与者 (年龄在60-75岁) 患有SCF.
- 每天摄入5.7g的NWT-03或安慰剂.
- 使用CANTAB评估认知功能;通过ASLMRI测量CBF;分析血清BDNF水平.
主要成果:
- NWT-03的耐受性很好,并且符合标准.
- 没有观察到对认知表现或CBF的整体影响.
- 后期分析显示,女性的执行功能 (多任务处理,空间工作记忆) 显著改善,但男性没有.
- 没有检测到血清BDNF水平的变化.
结论:
- 长期的NWT-03消费增强了SCF妇女的多任务处理和工作记忆.
- NWT-03没有影响大脑血管功能.
- 在执行功能中观察到的性别差异需要进一步调查.
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