用Suaeda salsa (L.) Pall改善功能性消化不良,通过调节脑肠和肠道微生物群结构来调节
Wenjun Zhang1, Xueyu Wang1, Shuanghui Yin1
1School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, 130117, Jilin, China.
European journal of nutrition
|May 4, 2024
概括
苏亚达汁提取物通过增强肠道运动性和恢复微生物群平衡,改善小鼠的消化不良. 这项研究透露了通过"大脑-肠-肠微生物群"轴的治疗机制.
科学领域:
- 药理学和传统医学的医学.
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 传统的中国草药Suaeda salsa (S. salsa) 以其消化特性而闻名.
- 了解S. salsa的化学成分和作用机制对于其治疗应用至关重要.
- 消化不良或消化不良综合征是一种常见的疾病,具有复杂的潜在机制.
研究的目的:
- 为了确定S. salsa.的化学成分.
- 探索S. salsa在治疗消化不良综合征中的作用机制.
- 研究S. salsa对胃排空,肠道推进和肠道微生物群的影响.
主要方法:
- 使用柱状染色学和核磁共振,从S. salsa中分离和结构性表征化合物.
- 在小鼠中建立食物积累模型.
- 评估胃排空,肠道推进,结肠病变,血清类激素,蛋白质表达和肠道微生物群结构.
主要成果:
- 他们分离了10种化合物,包括纳灵宁,hesperetin和luteolin.
- S. salsa水性提取物通过增加胃排空和推进速度,改善了结肠病理和肠周平静.
- 治疗调节了肠道激素,调高了c-kit,SCF和GHRL蛋白质,恢复了肠道微生物群平衡,具有剂量依赖的影响.
结论:
- 在小鼠模型中,S. salsa对消化不良表现出治疗作用.
- 这项研究为S. salsa通过"大脑-肠-肠微生物群"轴的消化作用提供了第一个机械洞察力.
- 这项研究为进一步研究S. salsa.的活性成分提供了实验基础.
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