美国黑人和白人女性代谢概况的差异:来自两个潜在队列的分析
Emma E McGee1,2,3, Oana A Zeleznik4, Raji Balasubramanian5
1Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. emcgee@hsph.harvard.edu.
European journal of epidemiology
|May 4, 2024
概括
黑人和白人女性表现出显著的代谢差异,黑人女性表现出许多代谢物的较低水平. 即使控制了风险因素,这些差异仍然存在,这突显了在代谢学研究中需要多样化的需要.
科学领域:
- 代谢学 代谢学 代谢学
- 公共卫生 公共卫生
- 健康差异 在健康上的差异
背景情况:
- 代谢学在公共卫生方面越来越重要,但黑人女性在研究中代表性不足.
- 如果代谢特征不同,代表人数不足可能会加剧现有的黑人-白人健康差异.
- 这项研究解决了了解代谢概况的种族差异的需要.
研究的目的:
- 为了估计美国黑人和白人女性之间的代谢差异.
- 调查这些差异是否在考虑风险因素后仍然存在.
- 为更公平的代谢学公共卫生应用提供数据.
主要方法:
- 利用了来自两个前性队列的数据:护士健康研究 (NHS) 和妇女健康倡议 (WHI).
- 测量了334种血代谢物,使用液体染色学-并联质谱法.
- 采用线性回归,代谢物缩分析和逆几率比重用于风险因子均等.
主要成果:
- 在NHS中测量的大多数代谢物中观察到显著的黑白代谢体差异.
- 黑人女性通常对许多代谢物的平均水平较低,包括N6,N6-dimethyllysine.
- 代谢基组丰富显示了黑人女性的甘油三水平较低和胆固醇的水平较高;结果在WHI中复制.
结论:
- 黑人和白人女性之间存在代谢特征的显著差异.
- 即使控制了共同的风险因素,这些差异仍然存在.
- 在未来的代谢学研究中优先考虑种族代表性对于公共卫生公平至关重要.
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