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适应pH值的生物粘合剂,具有强大而稳定的湿粘度,用于胃潰瘍愈合
Ruilin Xie1, Xueli Yan2, Jing Yu3
1Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, PR China; Engineering Research Center of Energy Storage Materials and Devices, Ministry of Education, School of Chemistry, Xi'an Jiaotong University, Xi'an, 710049, PR China.
一种新的生物粘合剂,由电离的N-烯基氨 (iAPA) 和N-[tris (hydroxymethyl) methyl]烯胺 (THMA) 制成,有效治疗胃. 这种内镜可输送的水凝通过强烈粘附于组织并保护其免受酸性影响,促进快速愈合.
科学领域:
- 生物材料科学 生物材料科学
- 胃肠病学 胃肠病学
- 聚合物化学 聚合物化学
背景情况:
- 开发有效的内镜交付生物粘合剂来治疗胃潰瘍是一项挑战.
- 现有的治疗方法在酸性胃环境中难以强大的粘附和保护.
研究的目的:
- 创建一个先进的生物粘合剂,用于内镜输送和强大的粘附到胃组织.
- 通过增强的界面相互作用和伤口保护,促进胃的愈合.
主要方法:
- 通过自由基聚合来合成一种生物粘合剂,该聚合物是电离化的N-烯烯氨酸 (iAPA) 和N-[tris (hydroxymethyl) methyl]烯胺 (THMA).
- 评估了前体聚合物溶液的粘度,用于内镜输送.
- 研究了IAPA在胃酸中的水友性-性过渡,以触发现场凝.
- 在大鼠胃模型中评估了水凝的稳定性,湿粘强度和体内疗效.
主要成果:
- 前体溶液的粘度较低,适合用于内镜输送.
- 胃酸触发了in-situ凝,形成了一个稳定的水凝,具有强大的湿粘度 (33.4 kPa).
- 生物粘合剂保护胃伤口免受酸和素的影响,抑制炎症,促进毛细血管的形成,加速大鼠的愈.
结论:
- 开发的IAPA/THMA生物粘合剂为胃治疗提供了一个有前途的,内镜可提供的解决方案.
- 它独特的凝机制和强大的粘合力有助于有效地保护伤口并促进加速愈合.
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