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细菌对抗微生物光动力学疗法的耐药性:一个关键的更新

Amanda Koberstain Surur¹, Analú Barros de Oliveira², Sarah Raquel De Annunzio¹

¹São Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, São Paulo, Brazil.

Journal of photochemistry and photobiology. B, Biology

|May 4, 2024

概括

抗微生物光动力疗法 (aPDT) 对抗生素耐药细菌显示出有前景. 本综述检查了细菌在重复治疗后是否对aPDT产生耐药性,探索了潜在的耐药性机制.

科学领域:

微生物学微生物学
照相医疗 (photomedicine) 是一种医学技术.
传染性疾病传染性疾病

背景情况:

细菌抗生素耐药性构成了全球主要的健康威胁,需要新的治疗策略.
抗微生物光动力疗法 (aPDT) 提供了一种替代方法来对抗对常规抗生素无反应的感染.
细菌在重复应用后可能对aPDT产生耐药性的可能性仍然是科学辩论的主题.

研究的目的:

审查自2010年以来针对细菌的连续抗微生物光动力疗法 (aPDT) 应用的研究.
在aPDT协议中使用的常见光敏感剂 (PSs) 的识别.
调查潜在的细菌耐受性或对aPDT的抗性机制.

主要方法:

2010年以后发表的研究的系统文献综述.
专注于涉及重复aPDT循环的研究,特别是对亚致死剂的研究.
分析报告的细菌反应和识别的耐药性途径.

主要成果:

在连续的aPDT治疗中使用的光敏剂 (PSs) 的概述.
鉴定可能参与aPDT耐受性/耐药性的细菌防御机制.
讨论影响耐药性发展的因素,包括排泄,生物膜形成和酶系统.

结论:

虽然aPDT是有效的,但细菌耐药性发展的可能性需要进一步调查.
了解耐药机制对于优化aPDT协议和确保长期疗效至关重要.
需要进一步的研究,以充分阐明细菌适应多次aPDT暴露的动态.

关键词:

抗微生物光动力学疗法的耐药性.细菌耐药性的细菌耐药性生物膜是一种生物膜.氧化应激是一种氧化应激.在致命后的剂量.连续的应用程序.

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